This benchtop wave reactor is an ideal choice for small scale production, or process testing. Sartorius supports every customer with a fully scalable and interchangeable range of singleuse or glass and stainless steel bioreactor solutions. Standalone instruments for wave bioreactor 210 and. We have 1 ge readytoprocess wave 25 manual available for free pdf download. Cytiva readytoprocess cbcu bioreactor system by cytiva. Periodically during perfusion, feed culture media is added and cellfree culture media removed. Contact a supplier or the parent company directly to get a quote or to find out a price or your closest point of sale. For more information, please visit us at ge wave 2. For further information regarding the use of wave bioreactor 210, wave bioreactor 2050 and wavepod ii1, refer to wave. Intracellular, erretention hdel wave mixed bioreactor, fedbatch. Ge wave 2050eht bioreactor 50 liter tray with warranty. Equipment description the sartorius biostat rm 2050 wave bioreactor provides a reliable, robust and easy to program wave mixed reaction system that fits easily on your benchtop. Ge wave biotech system 2050 eh bioreactor cell culture. Biosafety cabinets 5 manual and automated cell counting, cedex.
Ge healthcare readytoprocess wave 25readytoprocess wave 25 bioreactor system can now be operated in both single and dual culture modes. The filled cellbag bioreactor is heavy and must be lifted with care. Readytoprocess wave 25 ge healthcare life sciences. In the us the wave bioreactor system is sold for research. This bioreactor is an ideal choice for applications in cell culture, cho cells, vaccination production, protein manufacturing, and much more. When ge healthcare life sciences decided to upgrade the existing wave bioreactor system, one of the main goals was to provide advanced measurement and control features and, at the same time, keep the simplicity and inherent ease of use that comes with the rocking bioreactor technology. It is based on a wellknown rocking technology providing mixing and aeration to the culture, which is maintained in an inflated, disposable cellbag bioreactor cultivation chamber. Documents document view page ge wave bioreactor 210 20. You can save paper and ink by printing only the pages for the language you need. Find out all of the information about the ge healthcare life sciences product. Box 27 piscataway, nj 0885527 usa ge healthcare japan corporation sanken bldg. Installation instructions bell alarm for 32005000 ampere breakers wavepro power circuit breaker accessories. If printing is required, note that some manuals include multiple languages.
Ge healthcare 28988000 wave 25 readytoprocess rocker. Ge readytoprocess wave 25 operating instructions manual. Ge healthcare 28988000 wave25 readytoprocess rocker. Adenovirus production in singleuse readytoprocess wave 25. To prevent the bioreactor system units from accidentally being pulled from the bench, make sure that all. All parts are laserlabelled with part numbers and have certificates of origin. Equipment description the ge wave 2050ehtd bioreactor system is flexible in design and robust in execution. Standing for rocking motion, the biostat rm is a customizable wave bioreactor thats compatible with flexsafe rm bags to use for a whole host of cell lines.
We manually measure the geometry of an inflated cellbag 10 l cellbag of a wave bioreactor 2050, ge healthcare. Dasgip benchtop bioreactors feature an autoclavable glass body and a stainless steel head plate. We found that although this system initializes successfully and the heating works, the rocking function does not respond after init. Singleuse wave bioreactor systems xcellerex xdr cell culture suite aktaready and readytoprocess prepacked columns 20 2012 2014 2015 billingham, uk driven by the industry need for cgmp mammalian cell culture biomanufacturing capacity four successful capacity expansion projects on two continents. Operating instructions manual ge readytoprocess wave 25 operating instructions manual 172 pages bioreactor system.
Ge wave 2050eht bioreactor 50 liter tray with warranty see. The ability to handle the bioreactor in a tilt position facilitates sampling and harvest. Ge healthcare life sciences data file 29061852 aa cell expansion xuri cell expansion system w25 the singleuse xuri cell expansion system w25 is a reliable and intuitive cell expansion device for working volumes up to 25 l fig 1. Because of its easy handling, low contamina tion rates below 1%, and the cell amounts achiev ed normally ranging between. Ge healthcares wave bioreactor systems 210 and 2050 the wave bioreactor system is a cell culture device suitable for applications in gene and cell therapy in regenerative medicine, and for production of human therapeutics like monoclonal antibodies and vaccines. Caution only cellbag bioreactors approved by ge for readytoprocess wave 25 may be used together with the equipment. This not only reduces the risk of contamination and operator variability but frees up your time and work. Data storage and communication all run data and control parameters are stored on two. The system is based on the wellknown wave rocking technology that provides mixing and aeration to the. This system is an ideal choice for applications in cell culturing, cho cells, vaccination production, protein manufacturing, and much more. Protocols on inoculation, monitoring, and sampling are also outlined in this chapter. Owners manuals and installation instructions ge appliances. Contact a supplier or the parent company directly to. Ge title or job number 92911 improved cell growth in the wave bioreactor system with upgraded software version 2.
Cellbag bioreactors the rocking motion of the platform induces waves to mix and transfer oxygen to the culture medium to create an optimal environment for cell growth fig 2 and to reach high cell densities. A 20% o 2 and 5% co 2 gas mixture flowed into the head space at a rate of 0. Standalone instruments for wave bioreactor 210 and 2050. Readytoprocess wave 25 bioreactor system was developed with the goal of. Cytiva readytoprocess wave 25 rocking bioreactor system by cytiva. This bioreactor is modular and can be expanded up or paired down depending on needs. Ge healthcare representative for the most current information. In september with the launch of the new wave 25 bioreactor, the cell culture dish and ge healthcare life sciences launched a contest looking for the most innovative ways wave bioreactors had been used to advance technology. This chapter details how to initiate a culture, install the xuri ces w25, and install a 2 l cellbag bioreactor. The controller is engineered to optimize capital costs without sacrifi cing functionality. Readytoprocess wave 25 laboratory equipment pdf manual download. Owner manuals, installation instructions ge appliances. Recently, a number of manufacturingscale perfusion or perfusioncapable bioreactors have been launched table 2, and this includes the cur.
Cart cell therapies have been successfully generated using the xuri ces w25 system, which reduces manual labor compared with static culturing methods. The singleuse readytoprocess wave 25 bioreactor system is a reliable and intuitive cell culture device for working volumes up to 25 l. Xuri cell expansion system w5 ge healthcare life sciences. Ge life sciences wave bioreactor 2050eh rockerdualwa. Perfusion culture is enabled if an external instrument module for perfusion cultivation, perfcont2e, is installed. Scaleup without tedious sequential transfers using singleuse cellbag bioreactors that can accommodate working volumes up to 25 l, ensuring an entire therapeutic dose can be obtained in a single bioreactor. Ge wave biotech irc sterile tube fuser stfircww low weld use stfir w. View online or download ge readytoprocess wave 25 operating instructions manual. The readytoprocess wave 25 rocker features integrated temperature sensors and load cells, designed for convenient handling and control of cell cultures up to 25 l. Wave bioreactor 200 system ge healthcare life sciences. Beckman coulter biomek fx manual created by alex ryndau march 8, 2016 category. View and download ge readytoprocess wave 25 operating instructions manual online.
The wave bioreactor system produces viruses under complete containment without the need for biosafety cabinet. Cart cell expansion in a xuri cell expansion system w25. Bioreactor spinner flask stainless dip tubes and hose barb. The wide top opening facilitates for the user to interact with the culture without removing the lid. The biopharma business o f ge healthcare was acquired by danaher on 31 march 2020 and now operates under the cytiva brand. Bioreactor systems for in vitro production of foreign. It also includes relevant guidance for practical handling and maintenance of the system units. Ge readytoprocess wave 25 operating instructions manual pdf. The thermo scientific hyperforma singleuse bioreactor s. This process commonly takes up to 3 weeks and requires numerous manual handling steps, making it timeconsuming, laborious and susceptible to contaminations. Ge healthcare wave products group is a researchbased company that. Find your appliances installation instructions andor learn about the use and care of your appliance with our online database of owners manuals, installation instructions, and energy guides. The recently launched readytoprocess wave 25 bioreactor. Documents document view page beckman coulter biomek fx manual.
Readytoprocess wave 25 bioreactor system can be operated in single or dual culture. Unbranded 2input 1output 12 long bioreactor vessel chamber. Biostat rm 20 50 basic is a perfectly sized, singleuse, wave mixed benchtop bioreactor for standalone use. Ge healthcare life sciences the wave bioreactor system was the first. Scope of this document this manual covers the readytoprocess wave 25 system, including the rocker, gas mixer and doph controller cbcu, pump, unicorn software and accessories.
Ge biotech wave 2 10 eh bioreactor is available from the lab world group. Ge healthcare ge wave ge wave bioreactor 210 2050 tags. The system handbook provides you with instructions and information how to run the. Wave 25 bioreactor system intellectual property notice. Ge healthcare life sciences data file 28952058 ac wave bioreactor 210 and 2050 systems wave bioreactor 210 and 2050 systems fig 1 are part of ge healthcare life sciences readytoprocess platform of readytouse products. Ge wave biotech bioreactor sps gas mix 20b monitor card. It provides gas to the culture, and monitors ph andor dissolved oxygen. Pdf evaluation of a novel wave bioreactor r cellbag. The system is a cell culture device for the production of recombinant proteins in mammalian and insect cell lines in batch, fedbatch, and. Ge healthcare cell therapy steve hawthorn september 1st 2011. Sartorius biostat rm 2050 wave bioreactor the lab world. The wave bioreactor allows you to cultivate high density expansion of cells, while maintaining the homogenous phenotypic and functional characteristics reducing production time by nearly 60% of. Combining two wellestablished technologies, that is, wave bioreactors and. Ge healthcare life sciences readytoprocess platform of readyto use products, cellbag bioreactors require no sterilization or cleaning steps.
Thesystem handbookprovides you with instructions and information how to run the readytoprocess wave 25 bioreactor system. The high oxygen supply capability of the wave bioreactor system makes it ideal for insect cell culture. Wave biotech 500l rocker, hyclone sub stirred tank, xcellerex 1,000l stirred tank bioreactor integration challenge. Locate your appliances owners manual or installation instructions by model number by visiting us at. The generous tray can support cell bags from 100ml up to 20 l, 50l with a different tray and rocks anywhere from 2. This manual provide you with the instructions needed to handle wave bioreactor system optional standalone instruments. The g3lite bioreactor controller leverages the latest technologies, including singleuse sensors and finesse trubio software. Any use of unicorn is subject to ge healthcare standard software end. Linnea pauler, ge healthcare, for invaluable advise regarding cells, and cell bags. Xuri cell expansion system w25 cytiva, formerly ge. Money back guarantee ensures you receive the item you ordered or get your money back. Ge wave bioreactor 210 2050 systems operating manual. The biostat rm basic rocking platform with an integrated local controller, air co2 mixing module and optional load cells is the optimal choice. The ergonomic rocker design makes handling convenient and easy.
The gentle waves created by the rocker unit means the media surface is constantly renewed, giving you low sheer and bubble free aeration. Ge wave bioreactor system 2050 eht with wavepod ii. Enduser license agreement for readytoprocess wave 25 system. The cbcu is a component of the readytoprocess wave 25 bioreactor system. A model 2050 ehtd wave bioreactor system ge healthcare life sciences served as the rocking platform for both the 2l and 20l bags, maintaining cultures at a temperature of 37 c, a 16rpm rocking speed, and a 7 rocking angle. Working volumes for xuri w25 cellbag bioreactors bioreactor working volume cellbag 2l 300 ml to 1 l cellbag 10l 500 ml to 5 l cellbag 20l 1 to 10 l cellbag 50l 5 to 25 l fig 7. Readytoprocess wave 25 rocker ge healthcare life sciences.
Wave bioreactor systems 210 and 2050 ge healthcare life. Ge healthcare life sciences data file 290237 aa wave bioreactor 200 system wave bioreactor 200 system fig 1 is part of ge healthcare life sciences readytoprocess platform of readytouse products. It features an exchangeable bag holder to fit bags with a total volume of 1 50 l. This task is not trivial and may require timeconsuming, manual. Ge wave biotech irc sterile tube fuser stfircww low weld use stfir wwarranty. Download a digital copy of your owners manual, use and care manual, installation information, and energy guides. Ge wave biotech system 2050 eh bioreactor cell culture fermentor mixer eht. Your guide to upstream processing solutions from research to. A range of fittings can be used with the cellbag bioreactor. Rocking bioreactor systems with singleuse bags for suspension cell culture or adherent cell culture on microcarriers. Wave bioreactor systems 210 and 2050 ge healthcare.
Ge healthcare uk limited amersham place little chalfont buckinghamshire, hp7 9na uk ge healthcare europe, gmbh munzinger strasse 5 d79111 freiburg germany ge healthcare biosciences corp. Ge healthcare wave biotech airpump 20 w power supply. Ge healthcares wave bioreactor systems from cytiva. Jan 22, 2021 the ge wave 2050eht bioreactor system is flexible in design and robust in execution. The ge wave 2050eht bioreactor system is flexible in design and robust in execution. Culture medium and cells are loaded into a single use, presterilized bag known. Ge wave biotech bioreactor system 210eh 210 eh wwarranty.
It is based on a wellknown rocking technology providing mixing and aeration to the culture, which is maintained in an. The gentle wave action limits shear stress on the cells in comparison to traditional stirredtank bioreactors. Pdf significant time savings with simplified cell culturing. Ge healthcare readytoprocess wave 25 community, manuals. For major appliances many ge appliances products include a quick start guide only and not a full owners manual. The userfriendly and intuitive process picture pane enables manual. Data file 29061852 ad cell expansion xuri cell expansion. Key products, such as the wave bioreactor, wave mixer and sterile tube fuser. The array of automated multiparallel mini bioreactors and classic benchtop bioreactors supports fast and reliable development and characterization of your processes throughout all phases. Dasgip benchtop bioreactors for cell culture vessels. Our favorite innovative uses of the wave bioreactor technology. Disposable cellbag bioreactors for wave bioreactor systems. Designed to meet the demands of a regulated environment, the system offers reliable performance, accurate process control, and easeofuse.
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